Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 5/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9154581 | 1.00 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9155828 | 0.99 | PTGS2 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9161171 | 0.95 | PTGS2 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9152394 | 0.91 | TRPV3 (0.41) | PTGS2TRPV3P2RX7 | |
| SCHEMBL9155992 | 0.87 | TRPV3 (0.40) | PTGS2TRPV3P2RX7PDE2AMCHR1 | |
| SCHEMBL9159143 | 0.87 | TRPV3 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9156816 | 0.86 | GAA (0.35) | PTGS2GAAMAPT | |
| SCHEMBL9158940 | 0.86 | GAA (0.35) | PTGS2GAAMAPT | |
| SCHEMBL9157491 | 0.85 | PTGS2 (0.35) | PTGS2GAAMAPT | |
| SCHEMBL9160035 | 0.84 | GAA (0.35) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445248-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| WO-1991004248-A1 | PYRIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |