Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 5/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.37 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9152394 | 0.91 | TRPV3 (0.41) | TRPV3PTGS2P2RX7 | |
| SCHEMBL9161171 | 0.89 | PTGS2 (0.38) | TRPV3PTGS2P2RX7PDE2AMCHR1 | |
| SCHEMBL9155828 | 0.88 | PTGS2 (0.38) | TRPV3PTGS2P2RX7PDE2AMCHR1 | |
| SCHEMBL9154581 | 0.87 | PSEN1 (0.38) | TRPV3PTGS2P2RX7PDE2AMCHR1 | |
| SCHEMBL9158482 | 0.87 | PSEN1 (0.38) | TRPV3PTGS2P2RX7PDE2AMCHR1 | |
| SCHEMBL9159950 | 0.87 | TRPV3 (0.41) | TRPV3P2RX7 | |
| SCHEMBL9158975 | 0.83 | PTGS2 (0.37) | PTGS2P2RX7 | |
| SCHEMBL9158778 | 0.81 | DGAT1 (0.50) | TRPV3MCHR1 | |
| SCHEMBL9156338 | 0.81 | PIK3CD (0.37) | — | |
| SCHEMBL9158763 | 0.81 | DGAT1 (0.50) | TRPV3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445248-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| WO-1991004248-A1 | PYRIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |