Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23704878 | 0.69 | CHRNA1 (0.40) | ALDH1A1HCAR3HCAR2CHRNA1CHRNG | |
| SCHEMBL15996618 | 0.69 | MAOB (0.41) | HCAR3HCAR2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL9250653 | 0.68 | ALDH1A1 (0.42) | ALDH1A1DAOHCAR3HCAR2CHRNA1 | |
| SCHEMBL11832968 | 0.65 | ALDH1A1 (0.40) | ALDH1A1DAOHCAR3HCAR2CHRNA1 | |
| SCHEMBL991292 | 0.63 | SLC6A3 (0.47) | HCAR3HCAR2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL10971053 | 0.63 | CYP19A1 (0.69) | ALDH1A1DAOHCAR3HCAR2CHRNA1 | |
| SCHEMBL10527140 | 0.62 | — | — | |
| SCHEMBL10968783 | 0.62 | ALDH1A1 (0.40) | ALDH1A1HCAR3HCAR2CHRNA1CHRNG | |
| SCHEMBL11845278 | 0.62 | HSD11B1 (0.43) | ALDH1A1HCAR3HCAR2EGFRLMNA | |
| SCHEMBL9230998 | 0.62 | MAOB (0.43) | ALDH1A1DAOHCAR3HCAR2CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636119-A1 | PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021149-A1 | PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1993-10-28 | — | — | WO | disclosed |