Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164239 | 0.88 | ALDH1A1 (0.39) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL2945134 | 0.83 | POLB (0.41) | ALDH1A1MAPK1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL31228371 | 0.82 | ALDH1A1 (0.53) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL30115183 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL26658 | 0.79 | ALDH1A1 (0.56) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL8404254 | 0.76 | ALDH1A1 (0.49) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL9651210 | 0.75 | ALDH1A1 (0.42) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL9651204 | 0.75 | ALDH1A1 (0.42) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL5245374 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL25600101 | 0.74 | ALDH1A1 (0.46) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4444685-A | Stereospecific synthesis of thienamycin from penicillin | MERCK & CO., INC. (US) | 1984-04-24 | — | — | US | claimed |
| EP-0414904-B1 | PREPARATION OF ENOL SILYL ETHER COMPOUNDS | KANEGAFUCHI CHEMICAL IND (JP) | 1995-03-29 | — | — | EP | disclosed |
| US-5071966-A | PROCESS FOR PREPARING AN ENOL SILYL ETHER COMPOUND | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-12-10 | — | — | US | disclosed |
| EP-0414904-A1 | PREPARATION OF ENOL SILYL ETHER COMPOUNDS | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4525582-A | Silyl, benzyl, p-nitrobenyl, or methyl esters of diazoacetate, a synthon used in the conversion of penicillin to thienamycin | MERCK & CO., INC. (US) | 1985-06-25 | — | — | US | disclosed |
| US-4444685-A | Stereospecific synthesis of thienamycin from penicillin | MERCK & CO., INC. (US) | 1984-04-24 | — | — | US | disclosed |