Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30115183 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL31228371 | 0.88 | ALDH1A1 (0.53) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL8404254 | 0.84 | ALDH1A1 (0.49) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL23828169 | 0.83 | ALDH1A1 (0.59) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL5245374 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL25600101 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL27549934 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL4915829 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL13234406 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL13234395 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186827-A1 | Ectonucleotidase Inhibitors and Methods of Use Thereof | ANTENGENE THERAPEUTICS LIMITED (CN) | 2018-07-05 | — | — | US | disclosed |
| US-20180072742-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | ANTENGENE THERAPEUTICS LIMITED (CN) | 2018-03-15 | — | — | US | disclosed |
| US-20160090353-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2016-03-31 | — | — | US | disclosed |
| US-9238616-B2 | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| US-20150307442-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | ARBOR PHARMACEUTICALS, LLC | 2015-10-29 | — | — | US | disclosed |
| US-20130102641-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-8367722-B2 | Methods of using prodrugs of pregabalin | XENOPORT, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8168623-B2 | Prodrugs of GABA analogs, compositions and uses thereof | XENOPORT, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20120035258-A1 | METHODS OF USING PRODRUGS OF PREGABALIN | XENOPORT, INC. (US) | 2012-02-09 | — | — | US | disclosed |
| EP-1902714-B1 | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2012-01-11 | — | — | EP | disclosed |
| US-20040006132-A1 | Prodrugs of gaba analogs, compositions and uses thereof | ARBOR PHARMACEUTICALS, LLC | 2004-01-08 | — | — | US | disclosed |
| US-20030176398-A1 | Prodrugs of GABA analogs, compositions and uses thereof | HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT | 2003-09-18 | — | — | US | disclosed |
| WO-2002100347-A2 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2002-12-19 | — | — | WO | disclosed |
| EP-0414904-B1 | PREPARATION OF ENOL SILYL ETHER COMPOUNDS | KANEGAFUCHI CHEMICAL IND (JP) | 1995-03-29 | — | — | EP | disclosed |
| US-5071966-A | PROCESS FOR PREPARING AN ENOL SILYL ETHER COMPOUND | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-12-10 | — | — | US | disclosed |
| EP-0414904-A1 | PREPARATION OF ENOL SILYL ETHER COMPOUNDS | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4683296-A | ANTIBIOTICS, SILATION | BRISTOL-MYERS COMPANY (US) | 1987-07-28 | — | — | US | disclosed |
| CN-86102077-A | Carbonization penem intermediates preparation | — | 1987-01-28 | — | — | CN | disclosed |
| US-4525582-A | Silyl, benzyl, p-nitrobenyl, or methyl esters of diazoacetate, a synthon used in the conversion of penicillin to thienamycin | MERCK & CO., INC. (US) | 1985-06-25 | — | — | US | disclosed |
| US-4444685-A | Stereospecific synthesis of thienamycin from penicillin | MERCK & CO., INC. (US) | 1984-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186827-A1 | Ectonucleotidase Inhibitors and Methods of Use Thereof | NT5E, ENTPD5, NT5C2 | ALDH1A1 527/4885TDP1 504/4885MAPK1 4119/4885 |
| US-20160090353-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885TDP1 1112/4885MAPK1 4760/4885 |
| US-20150307442-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885TDP1 1112/4885MAPK1 4760/4885 |
| US-20180072742-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | NT5E, ENTPD5, NT5C2 | ALDH1A1 527/4885TDP1 504/4885MAPK1 4119/4885 |
| US-20040006132-A1 | Prodrugs of gaba analogs, compositions and uses thereof | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885TDP1 1112/4885MAPK1 4760/4885 |
| US-20120035258-A1 | METHODS OF USING PRODRUGS OF PREGABALIN | GABBR1, GABRB2, GABBR2 | ALDH1A1 606/4885TDP1 1583/4885MAPK1 4379/4885 |
| US-20130102641-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885TDP1 1112/4885MAPK1 4760/4885 |
| US-20030176398-A1 | Prodrugs of GABA analogs, compositions and uses thereof | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885TDP1 1112/4885MAPK1 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.