Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164714 | 0.88 | LIPG (0.41) | KDM4EKCNH2 | |
| SCHEMBL154243 | 0.85 | GABRA1 (0.40) | HTR2BHTR2AHTR2CDRD2KDM4E | |
| SCHEMBL28305445 | 0.82 | HTR2B (0.35) | HTR2BHTR2AHTR2CDRD2KDM4E | |
| SCHEMBL14012984 | 0.76 | MAOB (0.46) | HTR2BHTR2AHTR2CKDM4ECYP2D6 | |
| SCHEMBL9502970 | 0.73 | GABRA1 (0.42) | KDM4ELMNACYP3A4HTR1AADRA2A | |
| SCHEMBL7473196 | 0.71 | HTR2C (0.43) | HTR2BHTR2AHTR2CKDM4ELMNA | |
| SCHEMBL6912026 | 0.70 | HTR2A (0.34) | HTR2BHTR2AHTR2CDRD2KDM4E | |
| SCHEMBL4436510 | 0.70 | PARP1 (0.36) | ADRA2AADRA2BADRA1AALDH1A1 | |
| SCHEMBL5953765 | 0.69 | HTR2A (0.33) | HTR2BHTR2AHTR2CDRD2KDM4E | |
| SCHEMBL5954199 | 0.69 | HTR2A (0.36) | HTR2BHTR2AHTR2CDRD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |