Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 6/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754891 | 0.93 | MEN1 (0.51) | MEN1KMT2ALMNAMAPTZDHHC2 | |
| SCHEMBL9373248 | 0.87 | MEN1 (0.46) | MEN1KMT2ALMNAMAPTZDHHC2 | |
| SCHEMBL22450141 | 0.81 | MEN1 (0.61) | MEN1KMT2ALMNAMAPT | |
| SCHEMBL28298919 | 0.80 | KMT2A (0.58) | MEN1KMT2ALMNAMAPT | |
| SCHEMBL7069458 | 0.79 | ATM (0.47) | MEN1KMT2ALMNAMAPTZDHHC2 | |
| SCHEMBL31504001 | 0.78 | LMNA (0.50) | MEN1KMT2ALMNAMAPTZDHHC2 | |
| SCHEMBL3483514 | 0.78 | LMNA (0.50) | MEN1KMT2ALMNAMAPTZDHHC2 | |
| SCHEMBL11252540 | 0.78 | ACHE (0.52) | LMNAMAPTZDHHC2FAAH | |
| SCHEMBL14891873 | 0.78 | LMNA (0.50) | KMT2ALMNA | |
| SCHEMBL18082510 | 0.77 | MEN1 (0.47) | MEN1KMT2ALMNAMAPTFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5478830-A | Pyrazolo pyrimidines; inhibitors of acyl-coenzyme A and cholesterol acyltransferase; antihypercholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5318984-A | Anticholesterol agents which inhibit acetyl coenzyme A transferase | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0372445-B1 | Imidazoles for the treatment of atherosclerosis | DU PONT MERCK PHARMA (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5166214-A | Enzyme inhibitors for anticholesterol agents, enzyme inhibitor and cardiovascular disorders | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |
| WO-1991018885-A1 | IMIDAZOLES FOR THE TREATMENT OF ATHEROSCLEROSIS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-12 | — | — | WO | disclosed |
| EP-0372445-A1 | Imidazoles for the treatment of atherosclerosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-06-13 | — | — | EP | disclosed |