Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 10/20 | 0.52 |
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | THPO | P40225 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157251 | 0.93 | YAP1 (0.44) | DRD1DRD2CYP2D6THPOHSD17B10 | |
| SCHEMBL9161077 | 0.88 | DRD1 (0.55) | DRD1DRD2CYP2D6THPOHSD17B10 | |
| SCHEMBL9162204 | 0.88 | DRD1 (0.55) | DRD1DRD2CYP2D6THPOHSD17B10 | |
| SCHEMBL9158709 | 0.84 | YAP1 (0.44) | YAP1PRMT5GPR119 | |
| SCHEMBL9161002 | 0.84 | YAP1 (0.44) | ALOX15LMNAGAAYAP1MEN1 | |
| SCHEMBL9160083 | 0.83 | YAP1 (0.44) | ALOX15LMNAGAAYAP1MEN1 | |
| SCHEMBL10600866 | 0.82 | PTGDR2 (0.44) | DRD1DRD2CYP2D6THPOHSD17B10 | |
| SCHEMBL9165947 | 0.79 | ESR2 (0.39) | DRD1DRD2KDM4EMAPTDRD4 | |
| SCHEMBL10606169 | 0.77 | PTGDR2 (0.40) | DRD1DRD2CYP2D6THPOHSD17B10 | |
| SCHEMBL9160979 | 0.77 | DRD2 (0.55) | DRD1DRD2GFERDRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380355-B1 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0380355-A2 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4861771-A | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |