Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9165947 | 0.94 | ESR2 (0.39) | YAP1TLR9PRMT5HRH3PDE4B | |
| SCHEMBL9157251 | 0.88 | YAP1 (0.44) | YAP1PRMT5GHSRS1PR5 | |
| SCHEMBL9162086 | 0.84 | DRD1 (0.52) | YAP1PRMT5GPR119 | |
| SCHEMBL9160083 | 0.84 | YAP1 (0.44) | YAP1PRMT5GHSRGPR119 | |
| SCHEMBL10486477 | 0.82 | GHSR (0.43) | YAP1TLR9GHSRREV1 | |
| SCHEMBL9161002 | 0.80 | YAP1 (0.44) | YAP1PRMT5GHSRGPR119 | |
| SCHEMBL10606164 | 0.79 | PTGDR2 (0.41) | PDE4BS1PR5 | |
| SCHEMBL10600866 | 0.78 | PTGDR2 (0.44) | S1PR5 | |
| SCHEMBL10486490 | 0.72 | GHSR (0.44) | YAP1PRMT5GHSR | |
| SCHEMBL9157568 | 0.72 | YAP1 (0.46) | YAP1TLR9PRMT5TLR7GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380355-B1 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0380355-A2 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |