Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9162542 | 0.88 | HPGD (0.53) | BCL2MDM2MCL1ALDH1A1HPGD | |
| SCHEMBL9165974 | 0.75 | MAPT (0.37) | GAAALDH1A1MAPTPOLBTP53 | |
| SCHEMBL11789395 | 0.74 | CYP1A2 (0.53) | CYP1A2CYP2C9CYP2C19ALDH1A1HPGD | |
| SCHEMBL9166485 | 0.74 | ALDH1A1 (0.35) | ALDH1A1MAPTTP53KDM4E | |
| SCHEMBL9157928 | 0.72 | SMN1; SMN2 (0.37) | CYP1A2CYP2C9CYP2C19GAAMAPT | |
| SCHEMBL3387691 | 0.71 | SMN1; SMN2 (0.56) | BCL2MDM2MCL1CYP1A2CYP2C9 | |
| SCHEMBL3265133 | 0.69 | NPSR1 (0.45) | BCL2MDM2MCL1CYP1A2CYP2C19 | |
| SCHEMBL3262218 | 0.69 | NPSR1 (0.49) | BCL2MDM2MCL1CYP1A2CYP2C19 | |
| SCHEMBL10756621 | 0.69 | PPARG (0.53) | ALDH1A1KDM4E | |
| SCHEMBL9826688 | 0.69 | BCL2 (0.36) | BCL2MDM2MCL1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5442060-A | Treating hyperlipemia, atherosclerosis | MITSUBISHI KASEI CORPORATION (JP) | 1995-08-15 | — | — | US | disclosed |
| EP-0591830-A1 | Carboxamide and urea derivatives having ACAT-inhibiting activityM | Mitsubishi Chemical Corporation (JP) | 1994-04-13 | — | — | EP | disclosed |