Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9165736 | 0.82 | NAAA (0.51) | NAAAMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9168713 | 0.80 | NAAA (0.57) | NAAAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7150639 | 0.76 | LTA4H (0.56) | ALDH1A1MEN1HPGDKMT2AL3MBTL1 | |
| SCHEMBL9417656 | 0.76 | NAAA (0.54) | NAAAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL14064425 | 0.75 | ALDH1A1 (0.53) | NAAAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL14064319 | 0.75 | ALDH1A1 (0.53) | NAAAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL9164404 | 0.75 | PLA2G4B (0.49) | — | |
| SCHEMBL16692630 | 0.74 | HTT (0.68) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL3364812 | 0.74 | HTT (0.68) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL11973884 | 0.74 | HTT (0.68) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |