Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 11/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765887 | 0.82 | TBXAS1 (0.54) | PLOD2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL9164237 | 0.82 | CYP1A2 (0.42) | PLOD2ALDH1A1GPR52L3MBTL1LMNA | |
| SCHEMBL5162022 | 0.80 | ALDH1A1 (0.55) | PLOD2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL2228198 | 0.76 | ALDH1A1 (0.46) | PLOD2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL23926879 | 0.75 | L3MBTL1 (0.54) | PLOD2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL6900351 | 0.75 | ALDH1A1 (0.51) | PLOD2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL6511843 | 0.75 | MDM2 (0.62) | PLOD2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL27623816 | 0.74 | TBXAS1 (0.57) | TBXAS1TBXA2R | |
| SCHEMBL13898363 | 0.74 | MDM2 (0.47) | ALDH1A1L3MBTL1LMNACYP3A4TDP1 | |
| SCHEMBL82140 | 0.73 | ALDH1A1 (0.58) | PLOD2ALDH1A1APPGAAHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040753-C | Pyridine derivatives and the preparation thereof | ICI PLC (GB) | 1998-11-18 | — | — | CN | disclosed |
| US-5401849-A | FOR ANTAGONIZING THE ACTIONS OF, AND INHIBITING THE SYNTHESIS OF, THROMBOXANE A2 | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| EP-0329360-B1 | Pyridine derivatives | ICI PLC (GB) | 1994-08-03 | — | — | EP | disclosed |
| US-5248780-A | Thromboxane inhibitors | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1993-09-28 | — | — | US | disclosed |
| US-5166213-A | Antiischemic agents, cardiovascular disorders, antiasthmatics or antiinflammatory agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-11-24 | — | — | US | disclosed |
| CN-1035115-A | Pyridine derivate and preparation method thereof | ICI PLC (GB) | 1989-08-30 | — | — | CN | disclosed |
| EP-0329360-A2 | Pyridine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-08-23 | — | — | EP | disclosed |