Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457524 | 0.84 | MAPT (0.62) | MAPTALDH1A1LMNASERPINE1TP53 | |
| SCHEMBL11571840 | 0.80 | MAPT (0.86) | MAPTALDH1A1LMNASERPINE1TP53 | |
| SCHEMBL333291 | 0.79 | MAPT (0.67) | MAPTALDH1A1LMNASERPINE1TP53 | |
| SCHEMBL31384417 | 0.79 | MAPT (0.67) | MAPTALDH1A1LMNASERPINE1TP53 | |
| SCHEMBL11866382 | 0.78 | MAPT (0.55) | MAPTALDH1A1LMNASERPINE1TP53 | |
| Ethane SCHEMBL11534058 | 0.78 | MAPT (0.65) | MAPTALDH1A1LMNASERPINE1TP53 | |
| Ammonia Solution, Strong SCHEMBL28210514 | 0.78 | MAPT (0.65) | MAPTALDH1A1LMNASERPINE1TP53 | |
| SCHEMBL11804826 | 0.77 | LMNA (0.52) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL27611956 | 0.77 | MAPT (0.72) | MAPTALDH1A1LMNASERPINE1TP53 | |
| SCHEMBL9853488 | 0.77 | MAPT (0.63) | MAPTALDH1A1LMNASERPINE1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |