Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11866382 | 0.93 | MAPT (0.55) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL9164786 | 0.84 | MAPT (0.58) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL11630143 | 0.84 | GABRP (0.61) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL31384417 | 0.83 | MAPT (0.67) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL333291 | 0.83 | MAPT (0.67) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| Ethane SCHEMBL11534058 | 0.81 | MAPT (0.65) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL28210514 | 0.81 | MAPT (0.65) | MAPTALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL14319950 | 0.80 | LMNA (0.72) | MAPTALDH1A1LMNATP53HTT | |
| SCHEMBL14390473 | 0.80 | KMT2A (0.56) | MAPTALDH1A1TP53SMN1; SMN2GAA | |
| SCHEMBL9853488 | 0.80 | MAPT (0.63) | MAPTALDH1A1LMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493305-B1 | 2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA | GENZYME CORP (US) | 2015-03-25 | — | — | EP | disclosed |
| US-8980926-B2 | 2-aminoindole compounds and methods for the treatment of malaria | GENZYME CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980926-B2 | 2-aminoindole compounds and methods for the treatment of malaria | GENZYME CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20120232063-A1 | 2-Aminoindole Compounds And Methods For The Treatment Of Malaria | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2012-09-13 | — | — | US | disclosed |
| US-20120232063-A1 | 2-Aminoindole Compounds And Methods For The Treatment Of Malaria | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2012-09-13 | — | — | US | disclosed |
| WO-2011053697-A1 | 2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA | GENZYME CORPORATION (US) | 2011-05-05 | — | — | WO | disclosed |
| US-4182760-A | TRANQUILIZERS, SEDATIVES AND MUSCLE RELAXANTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-01-08 | — | — | US | disclosed |
| US-4141895-A | Hydroxyquinazolines and their use as intermediates for pharmaceutical agents | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-02-27 | — | — | US | disclosed |
| EP-0000332-A2 | Benzophenone anti-oximes, diazepin-N-oxides, their preparations and their use as pharmaceutical agents and as intermediates for the preparation of diazepines | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-01-24 | — | — | EP | disclosed |
| US-4082764-A | Methods for the production of 4H-s-triazolo[4,3-a][1,4]benzodiazepine 5N-oxides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1978-04-04 | — | — | US | disclosed |
| US-3947466-A | ANTIDEPRESSANTS, ANTIANXIETY | THE UPJOHN COMPANY (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232063-A1 | 2-Aminoindole Compounds And Methods For The Treatment Of Malaria | PNMT, AADAT, INMT | MAPT 621/4885ALDH1A1 1340/4885LMNA 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.