Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9161994 | 0.82 | NR4A2 (0.53) | CA1CA2NR4A2ALDH1A1KDM4E | |
| SCHEMBL9090774 | 0.80 | AMY1A (0.44) | TSHRMAPK1CASP1HSD17B10NR4A2 | |
| SCHEMBL9163823 | 0.80 | SMN1; SMN2 (0.51) | TSHRMAPK1CASP1HSD17B10CA1 | |
| SCHEMBL9159565 | 0.80 | HSP90AB1 (0.52) | NR4A2ALDH1A1KDM4EMAPT | |
| SCHEMBL9162830 | 0.80 | MAP2 (0.47) | TSHRMAPK1HSD17B10PDGFRBPDGFRA | |
| SCHEMBL9164555 | 0.78 | MAP4K4 (0.51) | NR4A2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9159337 | 0.77 | LMNA (0.43) | TSHRMAPK1CASP1HSD17B10NR4A2 | |
| SCHEMBL9161172 | 0.76 | ALDH1A1 (0.52) | MAPK1NR4A2ALDH1A1KDM4EHPGD | |
| Ammonia Solution, Strong SCHEMBL2249468 | 0.75 | ALDH1A1 (0.51) | MAPK1NR4A2ALDH1A1KDM4EHPGD | |
| SCHEMBL25493265 | 0.74 | NR4A2 (0.42) | KITNR4A2ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0354994-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-21 | — | — | EP | disclosed |