Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9168451 | 0.97 | MEN1 (0.34) | MEN1POLBKMT2AATMGPR3 | |
| Hydrochloric Acid SCHEMBL6557718 | 0.83 | MEN1 (0.40) | MEN1POLBKMT2AATMCYP1A2 | |
| Hydrochloric Acid SCHEMBL7940442 | 0.83 | DNMT1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL8674460 | 0.80 | CYP1A2 (0.32) | CYP1A2TSHRBCHEACHE | |
| Hydrochloric Acid SCHEMBL9226884 | 0.79 | SLC6A2 (0.32) | — | |
| Hydrochloric Acid SCHEMBL6557720 | 0.76 | GPR3 (0.34) | MEN1POLBKMT2AATMGPR3 | |
| SCHEMBL27534312 | 0.76 | CYP1A2 (0.33) | GPR3CYP1A2TSHRHTR2ABCHE | |
| Hydrochloric Acid SCHEMBL8678334 | 0.76 | GPR3 (0.32) | GPR3 | |
| Hydrochloric Acid SCHEMBL8674888 | 0.76 | BCHE (0.36) | BCHEACHE | |
| SCHEMBL7052516 | 0.75 | GPR3 (0.30) | GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420320-A | Method for preparing cyclopentadienyl-type ligands and metallocene compounds | PHILLIPS PETROLEUM COMPANY (US) | 1995-05-30 | — | — | US | disclosed |