SCHEMBL91672

SCHEMBL91672

Cc1cc(C)c(C(=O)Oc2ccc(S(F)(F)(F)(F)F)c(F)c2)c(F)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C19 P33261 1/20 0.34
KMT2A Q03164 5/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 2/20 0.33
CYP3A4 P08684 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33
POLB P06746 2/20 0.32
TP53 P04637 1/20 0.32
THRB P10828 1/20 0.32
GAA P10253 1/20 0.32
LMNA P02545 1/20 0.31
NPC1 O15118 2/20 0.30
CASP3 P42574 1/20 0.30
SENP8 Q96LD8 1/20 0.30
SENP7 Q9BQF6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL91785 0.95 MAPT (0.35) MAPTCYP1A2CYP2C19KMT2AALDH1A1
SCHEMBL91798 0.88 MAPT (0.36) MAPTCYP1A2CYP2C19KMT2AALDH1A1
SCHEMBL14075230 0.82 KMT2A (0.38) MAPTCYP1A2CYP2C19KMT2AALDH1A1
SCHEMBL91661 0.76 KMT2A (0.39) MAPTCYP1A2CYP2C19KMT2AALDH1A1
SCHEMBL17355723 0.76 KMT2A (0.41) MAPTCYP1A2CYP2C19KMT2AALDH1A1
SCHEMBL91741 0.75 ALDH1A1 (0.37) MAPTKMT2AALDH1A1MEN1CYP3A4
SCHEMBL91669 0.73 KMT2A (0.35) MAPTCYP1A2CYP2C19KMT2AALDH1A1
SCHEMBL9841817 0.72 RXRA (0.40) MAPTKMT2AALDH1A1MEN1HPGD
SCHEMBL9841437 0.71 KMT2A (0.50) MAPTKMT2AALDH1A1HPGDTHRB
SCHEMBL91703 0.71 KMT2A (0.33) MAPTCYP1A2CYP2C19KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129002-B2 Compounds for use in liquid crystal media MERCK PATENT GMBH (DE) 2012-03-06 US disclosed