Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9168598 | 1.00 | TSHR (0.43) | TSHRLMNATP53SMN1; SMN2ADORA3 | |
| SCHEMBL9168592 | 1.00 | TSHR (0.43) | TSHRLMNATP53SMN1; SMN2ADORA3 | |
| SCHEMBL7159469 | 0.83 | KDM4E (0.57) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL9203542 | 0.82 | TSHR (0.39) | TSHRLMNATP53SMN1; SMN2ADORA3 | |
| SCHEMBL11838136 | 0.82 | KDM4E (0.59) | TSHRLMNATP53SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL9215675 | 0.82 | TSHR (0.39) | TSHRLMNATP53SMN1; SMN2ADORA3 | |
| Hydrochloric Acid SCHEMBL9216303 | 0.82 | TSHR (0.39) | TSHRLMNATP53SMN1; SMN2ADORA3 | |
| SCHEMBL9203548 | 0.82 | ADORA3 (0.40) | TSHRLMNATP53SMN1; SMN2ADORA3 | |
| Hydrochloric Acid SCHEMBL9215684 | 0.81 | ADORA3 (0.39) | TSHRLMNATP53SMN1; SMN2ADORA3 | |
| Hydrochloric Acid SCHEMBL9216313 | 0.81 | ADORA3 (0.39) | TSHRLMNATP53SMN1; SMN2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5464844-A | [3H,7H]thiazole[3,4-a]pyridines having antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-11-07 | — | — | US | disclosed |