Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | NAAA | Q02083 | 3/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | MLYCD | O95822 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9168059 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2NAAAL3MBTL1CA2KDM4E | |
| SCHEMBL15923326 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2NAAAL3MBTL1CA2KDM4E | |
| SCHEMBL6258472 | 0.94 | SMN1; SMN2 (0.79) | SMN1; SMN2NAAAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL131829 | 0.89 | SMN1; SMN2 (0.87) | SMN1; SMN2NAAAL3MBTL1CA2ALDH1A1 | |
| SCHEMBL6535127 | 0.89 | SMN1; SMN2 (0.87) | SMN1; SMN2NAAAL3MBTL1CA2ALDH1A1 | |
| SCHEMBL658648 | 0.88 | L3MBTL1 (0.69) | SMN1; SMN2NAAAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL12516004 | 0.88 | SMN1; SMN2 (0.62) | SMN1; SMN2L3MBTL1KDM4EALDH1A1LMNA | |
| SCHEMBL27033126 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2NAAAKDM4EALDH1A1LMNA | |
| SCHEMBL6535319 | 0.85 | SMN1; SMN2 (0.74) | SMN1; SMN2NAAAL3MBTL1CA2LMNA | |
| SCHEMBL9171034 | 0.84 | NAAA (0.61) | SMN1; SMN2NAAAL3MBTL1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| CN-1088199-A | The aniline that N-replaces | HOFFMANN LA ROCHE (CH) | 1994-06-22 | — | — | CN | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |