SCHEMBL9169736

SCHEMBL9169736

Clc1nnnc(OCC2CO2)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 4/20 0.36
TSHR P16473 4/20 0.36
TP53 P04637 3/20 0.36
HIF1A Q16665 2/20 0.36
CYP3A4 P08684 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
GLA P06280 1/20 0.34
MAPT P10636 2/20 0.33
HPGD P15428 2/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
KMT2A Q03164 1/20 0.33
PPARG P37231 1/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
PKM P14618 1/20 0.33
FGFR1 P11362 1/20 0.30
SRC P12931 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9167426 0.85 TDP1 (0.36) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL9170950 0.78 TDP1 (0.41) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL11322031 0.71 CHRNB2 (0.49) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL1587650 0.70 TDP1 (0.38) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL10982331 0.67 TDP1 (0.45) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL1300440 0.64 TDP1 (0.42) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL3146505 0.64 ALDH1A1 (0.44) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL3146503 0.64 ALDH1A1 (0.44) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL11150188 0.64 TDP1 (0.47) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL4308247 0.63 TDP1 (0.41) TDP1ALDH1A1TSHRTP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0347828-B1 Compositions comprising polyphenylene ether-polyester copolymers from epoxytriazine-capped polyphenylene ethers GEN ELECTRIC (US) 1995-05-24 EP disclosed
EP-0347827-B1 Epoxytriazine-capped polyphenylene ethers and method of preparation GEN ELECTRIC (US) 1994-09-28 EP disclosed
EP-0374517-B1 Polyphenylene ether-polyamide copolymers from epoxytriazine-capped polyphenylene ethers GEN ELECTRIC (US) 1994-01-26 EP disclosed
US-5153267-A Molding materials for automobile parts; solvent resistance; workability GENERAL ELECTRIC COMPANY (US) 1992-10-06 US disclosed
US-5100961-A Solvent resistant molding materials GENERAL ELECTRIC COMPANY (US) 1992-03-31 US disclosed
US-5096979-A To form copolymers with polyamides and polyesters that have good melt strength for blow molding GENERAL ELECTRIC COMPANY (US) 1992-03-17 US disclosed
US-5089566-A Molding materials; compatibilizers for blends; engineering thermoplastics GENERAL ELECTRIC COMPANY (US) 1992-02-18 US disclosed
US-5068286-A Molding materials, epoxychlorotriazines as end capping agents GE PLASTICS JAPAN LTD. (JP) 1991-11-26 US disclosed
US-5041504-A Engineering thermoplastics GENERAL ELECTRIC COMPANY (US) 1991-08-20 US disclosed
US-4980415-A Compositions comprising polyphenylene ethers and reactive graft polymers GENERAL ELECTRIC COMPANY (US) 1990-12-25 US disclosed
EP-0395993-A2 Compositions comprising polyphenylene ethers and reactive graft polymers GENERAL ELECTRIC COMPANY (US) 1990-11-07 EP disclosed
EP-0374517-A2 Polyphenylene ether-polyamide copolymers from epoxytriazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1990-06-27 EP disclosed
EP-0349717-A2 Polyphenylene ether-polyester copolymers from epoxytriazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1990-01-10 EP disclosed
EP-0347827-A2 Epoxytriazine-capped polyphenylene ethers and method of preparation GENERAL ELECTRIC COMPANY (US) 1989-12-27 EP disclosed
EP-0347539-A2 Epoxytriazine-capped polyphenylene ethers and method for their preparation GENERAL ELECTRIC COMPANY (US) 1989-12-27 EP disclosed
EP-0347828-A2 Compositions comprising polyphenylene ether-polyester copolymers from epoxytriazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1989-12-27 EP disclosed