SCHEMBL91705

SCHEMBL91705

Cc1cc(C)c(C(=O)Oc2ccc3cc(-c4cc(F)c(C)c(F)c4)ccc3c2)c(C)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 2/20 0.41
KMT2A Q03164 5/20 0.38
ESR1 P03372 4/20 0.38
ESR2 Q92731 3/20 0.38
MEN1 O00255 2/20 0.38
NPC1 O15118 1/20 0.38
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
TDP1 Q9NUW8 1/20 0.36
HSD17B1 P14061 5/20 0.36
HSD17B2 P37059 5/20 0.36
ALDH1A1 P00352 2/20 0.35
ERN1 O75460 1/20 0.34
GBA1 P04062 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL91717 0.91 ERN1 (0.43) MAPTCYP1A2CYP2C19KMT2AESR1
SCHEMBL91716 0.82 MAPT (0.34) MAPTCYP1A2CYP2C19KMT2AESR1
SCHEMBL91740 0.82 MAPT (0.36) MAPTCYP1A2CYP2C19KMT2AMEN1
SCHEMBL91736 0.80 MAPT (0.39) MAPTCYP1A2CYP2C19KMT2AESR1
SCHEMBL91709 0.80 LMNA (0.38) MAPTCYP1A2CYP2C19KMT2AESR1
SCHEMBL91831 0.79 MAPT (0.36) MAPTCYP1A2CYP2C19TDP1
SCHEMBL17355723 0.79 KMT2A (0.41) MAPTCYP1A2CYP2C19KMT2AMEN1
SCHEMBL12226072 0.75 MAPT (0.48) MAPTCYP1A2CYP2C19KMT2ANPC1
SCHEMBL91754 0.75 MAPT (0.34) MAPTCYP1A2CYP2C19KMT2AESR1
SCHEMBL91791 0.74 KIF11 (0.35) MAPTCYP1A2CYP2C19ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129002-B2 Compounds for use in liquid crystal media MERCK PATENT GMBH (DE) 2012-03-06 US disclosed
US-7419706-B2 Liquid crystalline medium MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2008-09-02 US disclosed