Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170543 | 0.87 | RAB9A (0.35) | PTGER1PTGER4PTGER3PTGER2MAPT | |
| SCHEMBL9163418 | 0.86 | GAK (0.39) | GAKMAPTNPC1RAB9ANFKB1 | |
| SCHEMBL9174113 | 0.86 | CYP11B1 (0.41) | MAPTNPC1RAB9ASMN1; SMN2FYN | |
| SCHEMBL9167960 | 0.86 | KDR (0.36) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9166631 | 0.85 | NPC1 (0.36) | PTGER1PTGER4PTGER3PTGER2MAPT | |
| SCHEMBL9172018 | 0.84 | DHFR (0.39) | MAPTSMN1; SMN2FYNLTA4HKDM4E | |
| SCHEMBL9171209 | 0.84 | FYN (0.39) | GAKMAPTNPC1RAB9AFYN | |
| SCHEMBL9170564 | 0.84 | NPC1 (0.41) | PTGER1PTGER4PTGER3PTGER2MAPT | |
| SCHEMBL9171199 | 0.82 | HSD17B1 (0.38) | PTGER1PTGER4PTGER3PTGER2MAPT | |
| SCHEMBL9173574 | 0.81 | RAB9A (0.39) | PTGER1PTGER4PTGER3PTGER2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420128-A | Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0503099-A1 | PYRIMIDINE DERIVATIVE, PRODUCTION THEREOF, AND ANDROGEN INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-09-16 | — | — | EP | disclosed |