Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9466380 | 1.00 | HTR2C (0.37) | HTR2CDRD2DRD4 | |
| SCHEMBL9177692 | 0.90 | DRD2 (0.40) | DRD2 | |
| SCHEMBL9180804 | 0.90 | DRD2 (0.40) | DRD2 | |
| SCHEMBL9179801 | 0.88 | DRD4 (0.43) | DRD2DRD4 | |
| SCHEMBL9466287 | 0.88 | DRD4 (0.43) | DRD2DRD4 | |
| SCHEMBL9466851 | 0.87 | KDM4E (0.36) | HTR2C | |
| SCHEMBL9176524 | 0.87 | KDM4E (0.36) | HTR2C | |
| SCHEMBL9465763 | 0.85 | HTR2C (0.38) | HTR2C | |
| SCHEMBL9182178 | 0.85 | HTR2C (0.38) | HTR2C | |
| SCHEMBL9466843 | 0.81 | HTR7 (0.38) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |