Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9183269 | 0.87 | POLB (0.39) | TSHRMEN1KMT2AMAPTPOLB | |
| SCHEMBL9180804 | 0.84 | DRD2 (0.40) | DRD2 | |
| SCHEMBL9177692 | 0.84 | DRD2 (0.40) | DRD2 | |
| SCHEMBL9467119 | 0.83 | POLB (0.38) | TSHRMEN1KMT2AMAPTPOLB | |
| SCHEMBL9466855 | 0.83 | HTR1A (0.45) | — | |
| SCHEMBL9179801 | 0.82 | DRD4 (0.43) | DRD2DRD3 | |
| SCHEMBL9466287 | 0.82 | DRD4 (0.43) | DRD2DRD3 | |
| SCHEMBL9178717 | 0.82 | GAA (0.44) | TSHRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL9466094 | 0.82 | GAA (0.44) | TSHRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL9174152 | 0.81 | HTR2C (0.37) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |