Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178359 | 0.93 | DRD2 (0.41) | DRD2HTR1AHTR2A | |
| SCHEMBL9179387 | 0.86 | SIGMAR1 (0.53) | DRD2HTR1AHTR2A | |
| SCHEMBL9467335 | 0.86 | DRD2 (0.45) | DRD2 | |
| SCHEMBL9176453 | 0.86 | DRD2 (0.45) | DRD2 | |
| SCHEMBL9467334 | 0.85 | DRD4 (0.50) | DRD2 | |
| SCHEMBL9467351 | 0.85 | DRD4 (0.50) | DRD2 | |
| SCHEMBL9180749 | 0.83 | DRD4 (0.46) | — | |
| SCHEMBL9177231 | 0.83 | DRD4 (0.46) | — | |
| SCHEMBL1037294 | 0.82 | — | — | |
| SCHEMBL9178238 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |