Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962567 | 0.88 | DPP4 (0.40) | LMNACYP2C19HPGDKMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL1092533 | 0.86 | DPP4 (0.39) | LMNACYP2C19HPGDKMT2ATDP1 | |
| SCHEMBL1077218 | 0.80 | KDM4E (0.38) | LMNAHPGDKMT2ATDP1L3MBTL1 | |
| SCHEMBL12770109 | 0.74 | CYP2D6 (0.39) | LMNACYP2D6SRCMAPK1KMT2A | |
| Bicarbonate SCHEMBL9180912 | 0.73 | ALPL (0.42) | LMNACYP2C19HPGDCYP2D6SRC | |
| Hydrochloric Acid SCHEMBL9359182 | 0.71 | KDM4E (0.36) | LMNAKMT2ATDP1L3MBTL1 | |
| SCHEMBL776592 | 0.71 | CYP2C19 (0.35) | LMNACYP2C19HPGDCYP2D6SRC | |
| Hydrochloric Acid SCHEMBL10446062 | 0.71 | TSHR (0.35) | CYP2C19KMT2AL3MBTL1 | |
| Acetic Acid SCHEMBL7939756 | 0.68 | ALPL (0.41) | LMNACYP2C19HPGDCYP2D6SRC | |
| SCHEMBL11039316 | 0.67 | HPGD (0.46) | LMNACYP2C19HPGDCYP2D6SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5464538-A | Reverse osmosis membrane | THE DOW CHEMICAL COMPANY (US) | 1995-11-07 | — | — | US | disclosed |
| US-5310581-A | Photoresists, reacting photolabile onium with a photoreactive nucleophile, modified vinylbenzyl chloride polymer | THE DOW CHEMICAL COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| US-5238747-A | Compounds with onium groups cured with compound having nucleophilic groups; photoresists release agents | THE DOW CHEMICAL COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0220660-B1 | SEMI-PERMEABLES MEMBRANES PREPARED VIA REACTION OF CATIONIC GROUPS WITH NUCLEOPHILIC GROUPS | THE DOW CHEMICAL COMPANY (US) | 1992-03-11 | — | — | EP | disclosed |
| US-4839203-A | COVALENT BONDING PRODUCING A COMPOSITE | THE DOW CHEMICAL COMPANY (US) | 1989-06-13 | — | — | US | disclosed |
| US-4797187-A | COACERVATION OF CATIONS | THE DOW CHEMICAL COMPANY (US) | 1989-01-10 | — | — | US | disclosed |
| US-4704324-A | REVERSE OSMOSIS, GAS SEPARATION, ULTRAFILTRATION | THE DOW CHEMICAL COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| WO-1987002682-A1 | SEMI-PERMEABLE MEMBRANES PREPARED VIA REACTION OF CATIONIC GROUPS WITH NUCLEOPHILIC GROUPS | THE DOW CHEMICAL COMPANY (US) | 1987-05-07 | — | — | WO | disclosed |
| EP-0220660-A2 | Semi-permeables membranes prepared via reaction of cationic groups with nucleophilic groups | THE DOW CHEMICAL COMPANY (US) | 1987-05-06 | — | — | EP | disclosed |
| US-4469836-A | Perfluorocarbon based polymeric coatings having low critical surface tensions | THE DOW CHEMICAL COMPANY (US) | 1984-09-04 | — | — | US | disclosed |