Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440741 | 0.85 | TDP1 (0.43) | KDM4ETDP1GAAALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1092533 | 0.83 | DPP4 (0.39) | KDM4ETDP1ALDH1A1LMNACYP3A4 | |
| SCHEMBL8962567 | 0.81 | DPP4 (0.40) | KDM4ETDP1ALDH1A1LMNACYP3A4 | |
| SCHEMBL14361137 | 0.77 | HPGD (0.44) | TDP1GAAVDRALDH1A1LMNA | |
| SCHEMBL30518067 | 0.73 | KMT2A (0.49) | TDP1GAAALDH1A1LMNAMEN1 | |
| SCHEMBL30518105 | 0.73 | ALDH1A1 (0.61) | KDM4ETDP1GAAALDH1A1THRB | |
| SCHEMBL30518106 | 0.73 | ALDH1A1 (0.61) | KDM4ETDP1GAAALDH1A1THRB | |
| SCHEMBL30518098 | 0.73 | ALDH1A1 (0.61) | KDM4ETDP1GAAALDH1A1THRB | |
| SCHEMBL5328347 | 0.73 | ALDH1A1 (0.40) | KDM4ETDP1ALDH1A1LMNACYP3A4 | |
| Bicarbonate SCHEMBL9177243 | 0.71 | LMNA (0.41) | TDP1LMNAL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392982-B1 | Solvent stable membranes | WEIZMANN KIRYAT MEMBRANE PROD (IL) | 1994-12-14 | — | — | EP | disclosed |
| US-5039421-A | Acrylonitrile polymer | ALIGENA AG (CH) | 1991-08-13 | — | — | US | disclosed |