Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | GHSR | Q92847 | 3/20 | 0.54 |
| ▸ | KIF11 | P52732 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17145105 | 0.84 | GHSR (0.79) | KDM4EGHSRKIF11MAPTMEN1 | |
| SCHEMBL18394946 | 0.80 | GHSR (0.56) | KDM4EGHSRKIF11MAPTMEN1 | |
| SCHEMBL19032013 | 0.80 | MAPT (0.77) | KDM4EKIF11MAPTMEN1KMT2A | |
| SCHEMBL890773 | 0.80 | GHSR (0.69) | KDM4EGHSRMEN1KMT2A | |
| SCHEMBL9180954 | 0.79 | KDM4E (0.52) | KDM4EGHSRMAPTMEN1KMT2A | |
| SCHEMBL9176990 | 0.78 | KDM4E (0.64) | KDM4EGHSRKIF11MEN1KMT2A | |
| SCHEMBL22996085 | 0.78 | NR3C1 (0.45) | KDM4EKIF11MEN1KMT2A | |
| SCHEMBL20382321 | 0.78 | ALDH1A1 (0.64) | KDM4EGHSRMAPTMEN1KMT2A | |
| SCHEMBL20382322 | 0.76 | GAA (0.63) | KDM4EGHSRMEN1KMT2A | |
| SCHEMBL24380299 | 0.74 | KIF11 (0.45) | KDM4EKIF11MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | disclosed |
| CN-1050187-A | New quinoline compound and preparation method thereof | ICI PLC (GB) | 1991-03-27 | — | — | CN | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |