Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | MYH9 | P35579 | 1/20 | 0.32 |
| ▸ | MYH10 | P35580 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23920265 | 0.76 | PDE3B (0.38) | KMT2AMAPTKDM4ENPC1PKM | |
| SCHEMBL22085081 | 0.73 | SHMT2 (0.33) | KMT2AMAPTKDM4ENPC1PKM | |
| SCHEMBL22038216 | 0.64 | ALDH1A1 (0.44) | KMT2AMAPTMEN1KDM4ECYP1A2 | |
| SCHEMBL21277795 | 0.64 | — | — | |
| SCHEMBL9181853 | 0.62 | KMT2A (0.47) | KMT2AMAPTMEN1CYP3A4KDM4E | |
| SCHEMBL9183312 | 0.62 | PDE3B (0.46) | MAPTKDM4ENPC1 | |
| SCHEMBL9180106 | 0.62 | ALDH1A3 (0.32) | — | |
| SCHEMBL23750001 | 0.61 | SMN1; SMN2 (0.35) | KMT2AMAPTKDM4ELMNANPC1 | |
| SCHEMBL4764684 | 0.61 | SHMT2 (0.39) | KMT2AMAPTMEN1KDM4ECYP2D6 | |
| SCHEMBL9377708 | 0.61 | KMT2A (0.39) | KMT2AMAPTMEN1CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |