Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175519 | 0.86 | SHMT2 (0.34) | SHMT2ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL8780480 | 0.83 | PTPN1 (0.35) | SHMT2ALDH1A1KDM4EMAPTAPAF1 | |
| SCHEMBL9181125 | 0.82 | MAPT (0.35) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL2821603 | 0.82 | PTPN1 (0.40) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3014252 | 0.82 | ALDH1A1 (0.36) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL14311341 | 0.82 | ALDH1A1 (0.34) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL19211201 | 0.82 | ALDH1A1 (0.34) | ALDH1A1KDM4EHPGDCYP2D6MAPT | |
| SCHEMBL9176975 | 0.81 | KDM4E (0.32) | ALDH1A1KDM4EHPGDCYP2D6MAPT | |
| SCHEMBL472760 | 0.81 | PTPN1 (0.42) | LMNAL3MBTL1TDP1CES1TSHR | |
| SCHEMBL21065455 | 0.81 | PTPN1 (0.42) | LMNAL3MBTL1TDP1CES1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083630-B1 | PROCESS METHODS FOR PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2019-08-21 | — | — | EP | disclosed |
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1094816-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2008-12-10 | — | — | EP | disclosed |
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1237888-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6852745-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-08 | — | — | US | disclosed |
| US-6835741-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-28 | — | — | US | disclosed |
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-07-01 | — | — | US | disclosed |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-06-03 | — | — | US | disclosed |
| CN-1149196-C | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | ����˹�ж�-����˹˹������˾ | 2004-05-12 | — | — | CN | disclosed |
| WO-1992013853-A1 | PHARMACEUTICAL AGENT | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-08-20 | — | — | WO | disclosed |
| EP-0495948-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1992-07-29 | — | — | EP | disclosed |
| EP-0495626-A1 | Process for the preparation of tetrazole derivatives | ZENECA LIMITED (GB) | 1992-07-22 | — | — | EP | disclosed |
| EP-0495627-A1 | Boron compounds | ZENECA LIMITED (GB) | 1992-07-22 | — | — | EP | disclosed |
| CN-1059516-A | The preparation method of biphenylcarbonitriles | ICI LTD (GB) | 1992-03-18 | — | — | CN | disclosed |
| WO-1992002508-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-20 | — | — | WO | disclosed |
| EP-0470795-A1 | Process for the manufacture of nitriles | ZENECA LIMITED (GB) | 1992-02-12 | — | — | EP | disclosed |
| EP-0470794-A1 | Process for the preparation of nitriles | ZENECA LIMITED (GB) | 1992-02-12 | — | — | EP | disclosed |
| CN-1050187-A | New quinoline compound and preparation method thereof | ICI PLC (GB) | 1991-03-27 | — | — | CN | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | SHMT2 2378/4885ALDH1A1 1854/4885KDM4E 1602/4885 |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | SHMT2 2378/4885ALDH1A1 1854/4885KDM4E 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.