Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185826 | 0.94 | MAPT (0.41) | MAPTNPSR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9263551 | 0.86 | MAPT (0.54) | MAPTNPSR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9184152 | 0.84 | RAB9A (0.54) | MAPTNPSR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7623042 | 0.78 | MAPT (0.50) | MAPTNPSR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9183583 | 0.76 | TMEM97 (0.55) | MAPTNPSR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9186890 | 0.76 | DDAH1 (0.45) | MAPTRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL7631677 | 0.76 | RAB9A (0.42) | MAPTRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL9259620 | 0.75 | ADORA3 (0.47) | MAPTRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL9187035 | 0.75 | HPGD (0.46) | MAPTRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL9261566 | 0.74 | APP (0.47) | MAPTRAB9ADDAH1ADRA2CL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5451594-A | NEMATOCIDES, INSECTICIDES, MITICIDES AND FUNGICIDES | ZENECA LIMITED (GB) | 1995-09-19 | — | — | US | disclosed |
| EP-0660830-A1 | BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES | ZENECA LIMITED (GB) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006782-A1 | BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES | ZENECA LIMITED (GB) | 1994-03-31 | — | — | WO | disclosed |