Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 14/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312733 | 0.75 | PTGS1 (0.61) | CA1CA2PTGS1PTGS2ALOX5 | |
| SCHEMBL9627285 | 0.74 | CA1 (0.35) | CA1CA2PTGS1 | |
| SCHEMBL9627290 | 0.73 | — | — | |
| SCHEMBL803157 | 0.72 | CA2 (1.00) | CA1CA2PTGS1PTGS2 | |
| SCHEMBL2470646 | 0.71 | CA2 (0.70) | CA1CA2PTGS1PTGS2 | |
| SCHEMBL9180604 | 0.70 | PTGS1 (0.68) | CA1CA2PTGS1PTGS2ALOX5 | |
| SCHEMBL9457150 | 0.70 | SMPD3 (0.58) | CA1CA2PTGS1PTGS2ALOX5 | |
| SCHEMBL8766812 | 0.70 | PTGS1 (0.58) | CA1CA2PTGS1PTGS2ALOX5 | |
| SCHEMBL9179869 | 0.69 | PTGS1 (1.00) | CA1CA2PTGS1PTGS2ALOX5 | |
| SCHEMBL9185074 | 0.69 | PTGS1 (0.66) | CA1CA2PTGS1PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371438-B1 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER LAMBERT CO (US) | 1995-08-30 | — | — | EP | claimed |
| EP-0371438-A2 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1990-06-06 | — | — | EP | claimed |
| EP-0371438-B1 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER LAMBERT CO (US) | 1995-08-30 | — | — | EP | disclosed |
| US-5376670-A | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1994-12-27 | — | — | US | disclosed |
| US-5256680-A | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-10-26 | — | — | US | disclosed |
| US-5155122-A | Cyclooxygenase, lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0371438-A2 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |