SCHEMBL918174

SCHEMBL918174

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@H](OC(=O)Nc3ccccc3)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TYMP P19971 5/20 0.55
P2RY12 Q9H244 2/20 0.51
P2RY2 P41231 1/20 0.48
P2RY1 P47900 1/20 0.48
P2RY6 Q15077 1/20 0.48
PRMT6 Q96LA8 1/20 0.47
BMPR1B O00238 1/20 0.46
DNPH1 O43598 1/20 0.46
ADORA1 P30542 2/20 0.46
ADORA2A P29274 1/20 0.46
ADORA2B P29275 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL918173 1.00 TYMP (0.55) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL918537 0.95 TYMP (0.55) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL918538 0.95 TYMP (0.55) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL30396368 0.92 TYMP (0.58) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL30091055 0.92 TYMP (0.58) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL23650062 0.92 TYMP (0.58) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL6513309 0.92 TYMP (0.58) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL7708120 0.92 TYMP (0.58) TYMPP2RY12P2RY2P2RY1P2RY6
SCHEMBL6900160 0.90 TYMP (0.56) TYMPP2RY12ADORA1ADORA2AADORA2B
SCHEMBL6834984 0.90 TYMP (0.56) TYMPP2RY12P2RY2P2RY1P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8252919-B2 2′-hydroxy-protected ribonucleoside derivative and production method thereof KANEKA CORPORATION (JP) 2012-08-28 US disclosed
US-20110009609-A1 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF KANEKA CORPORATION (JP) 2011-01-13 US disclosed
EP-2258709-A1 2'-HYDROXYL-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND MANUFACTURING METHOD OF SAME Kaneka Corporation (JP) 2010-12-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009609-A1 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF RNASEL, RNASEH1, NUDT1 TYMP 183/4885P2RY12 3020/4885P2RY2 1868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.