Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.41 |
| ▸ | WNT3A | P56704 | 2/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785261 | 0.78 | LMNA (0.46) | TSHRLMNAHPGDMEN1KMT2A | |
| SCHEMBL9401553 | 0.77 | LMNA (0.43) | ALDH1A1TSHRLMNAHPGD | |
| SCHEMBL28652307 | 0.75 | ALOX15 (0.58) | ALDH1A1TSHRALOX15LMNARAB9A | |
| SCHEMBL7850510 | 0.75 | KMT2A (0.39) | ALDH1A1TSHRSMN1; SMN2LMNARAB9A | |
| SCHEMBL9148337 | 0.73 | LMNA (0.85) | ALDH1A1TSHRSMN1; SMN2ALOX15LMNA | |
| SCHEMBL7854655 | 0.73 | HPGD (0.43) | ALDH1A1LMNARAB9AHPGDNPC1 | |
| SCHEMBL7374457 | 0.73 | TACR1 (0.51) | ALDH1A1TSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9182128 | 0.72 | KMT2A (0.45) | ALDH1A1TSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3857509 | 0.72 | ALOX15 (0.62) | ALDH1A1TSHRALOX15LMNARAB9A | |
| SCHEMBL7374463 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TSHRSMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0617038-B1 | Preparation of carbonic anhydrase inhibitors | ALCON LAB INC (US) | 2001-09-05 | — | — | EP | claimed |
| EP-0617038-A1 | Preparation of carbonic anhydrase inhibitors | ALCON LABORATORIES, INC. (US) | 1994-09-28 | — | — | EP | claimed |
| EP-0617038-B1 | Preparation of carbonic anhydrase inhibitors | ALCON LAB INC (US) | 2001-09-05 | — | — | EP | disclosed |
| EP-0652218-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-07-11 | — | — | EP | disclosed |
| US-5585385-A | USEFUL IN TREATING DISORDERS OF MICTURITION; ADMINISTERING TO INHIBIT PLASMA EXTRAVASATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0652218-A1 | Heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1995-05-10 | — | — | EP | disclosed |