Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9189125 | 0.97 | CA14 (0.56) | CA14ALDH1A1MAPTHDAC3HDAC1 | |
| SCHEMBL12311224 | 0.81 | GBA1 (0.44) | ALDH1A1MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL9188875 | 0.81 | CCR6 (0.66) | CA14HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL30941664 | 0.80 | ROCK2 (0.41) | CA14HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL9180351 | 0.79 | CA14 (0.50) | CA14ALDH1A1MAPTSSTR4 | |
| SCHEMBL9891452 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL7983925 | 0.77 | L3MBTL1 (0.46) | CA14HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL1844315 | 0.77 | L3MBTL1 (0.46) | CA14HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL10126784 | 0.77 | MEN1 (0.53) | ALDH1A1MAPTMETAP2 | |
| SCHEMBL25046666 | 0.76 | L3MBTL1 (0.45) | CA14HDAC3HDAC1HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497202-B1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMA (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5217964-A | POLYAMINE THIOLS AS RADIOPROTECTIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0497202-A1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-05 | — | — | EP | disclosed |