Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186665 | 0.87 | CNR2 (0.40) | ALDH1A1LMNAMAPTKEAP1NFE2L2 | |
| SCHEMBL9185920 | 0.86 | CA12 (0.41) | ALDH1A1MEN1KMT2ACA2ALOX15 | |
| SCHEMBL9188254 | 0.85 | TDP1 (0.41) | ALDH1A1LMNAKMT2A | |
| SCHEMBL9285790 | 0.84 | APLNR (0.44) | ALDH1A1LMNAKEAP1NFE2L2 | |
| SCHEMBL9187495 | 0.81 | SIGMAR1 (0.43) | SIGMAR1PLCG1ALDH1A1MEN1KMT2A | |
| SCHEMBL9190309 | 0.74 | USP2 (0.46) | ALDH1A1LMNAKDM4EUSP2MMP9 | |
| SCHEMBL18992740 | 0.72 | ALDH1A1 (0.38) | SIGMAR1PLCG1GAAALDH1A1LMNA | |
| SCHEMBL22804712 | 0.71 | TSHR (0.38) | SIGMAR1PLCG1ALDH1A1LMNAMAPT | |
| SCHEMBL5441671 | 0.68 | CNR2 (0.50) | ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL9188734 | 0.67 | CA12 (0.46) | ALDH1A1LMNAMEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416286-B1 | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents | UNIV YALE (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5214068-A | Anticarcinogenic agents | YALE UNIVERSITY (US) | 1993-05-25 | — | — | US | disclosed |
| US-5101072-A | Anticancer agents, trypanocides | YALE UNIVERSITY (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0416286-A1 | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents | YALE UNIVERSITY (US) | 1991-03-13 | — | — | EP | disclosed |