Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.41 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13805751 | 0.82 | HCAR3 (0.51) | HCAR3NPSR1NEU3CDC25BL3MBTL1 | |
| SCHEMBL6801960 | 0.80 | NPSR1 (0.43) | HCAR3NPSR1NEU3CDC25BL3MBTL1 | |
| SCHEMBL6801964 | 0.80 | NPSR1 (0.43) | HCAR3NPSR1NEU3CDC25BL3MBTL1 | |
| SCHEMBL9196477 | 0.77 | HCAR3 (0.58) | HCAR3NPSR1SMN1; SMN2KDM4E | |
| SCHEMBL5405584 | 0.76 | CDC25B (0.53) | NPSR1NEU3CDC25BL3MBTL1SMN1; SMN2 | |
| SCHEMBL3968070 | 0.76 | SLC9A1 (0.64) | NPSR1CDC25BSMN1; SMN2KDM4EPKM | |
| SCHEMBL2617356 | 0.76 | HCAR3 (0.59) | HCAR3KDM4E | |
| SCHEMBL29114280 | 0.76 | HCAR3 (0.59) | HCAR3SMN1; SMN2KDM4EPTGFRHTT | |
| SCHEMBL22938569 | 0.76 | HCAR3 (0.59) | HCAR3NPSR1KDM4EPTGFRHTT | |
| SCHEMBL31473433 | 0.76 | GAA (0.61) | HCAR3CDC25BL3MBTL1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416499-B1 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AG (DE) | 1995-04-26 | — | — | EP | disclosed |
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |
| EP-0416499-A2 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-13 | — | — | EP | disclosed |