Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193484 | 0.90 | TYR (0.38) | ALOX5 | |
| SCHEMBL9195084 | 0.86 | GABRA1 (0.38) | DHFR | |
| SCHEMBL9190686 | 0.85 | ALOX5 (0.33) | DHFRHMGCRALOX5 | |
| SCHEMBL8573280 | 0.84 | DHFR (0.35) | DHFRHMGCRALOX5CNR1CNR2 | |
| SCHEMBL9193207 | 0.84 | DHFR (0.35) | DHFRHMGCRALOX5CNR1CNR2 | |
| SCHEMBL9193322 | 0.80 | GABRA1 (0.42) | — | |
| SCHEMBL9188546 | 0.79 | TYR (0.37) | ALOX5 | |
| SCHEMBL9193214 | 0.77 | ESR1 (0.39) | ALOX5 | |
| SCHEMBL8573273 | 0.75 | ALOX5 (0.35) | DHFRALOX5 | |
| SCHEMBL2678602 | 0.75 | HMGCR (0.39) | DHFRHMGCRALOX5CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464844-B1 | Novel bis (4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1995-12-27 | — | — | EP | disclosed |
| US-5304668-A | Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents | MERRELL DOW PHARMACEUTICALS (US) | 1994-04-19 | — | — | US | disclosed |
| US-5281738-A | Anticholesterol agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0464844-A1 | Novel bis (4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |