Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Isopropylhydroxylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropylhydroxylamine SCHEMBL64261 | 0.80 | — | — | |
| Isopropylhydroxylamine SCHEMBL28685366 | 0.80 | CA2 (0.53) | CA2CA14 | |
| Sulfuric Acid SCHEMBL10528253 | 0.79 | TDP1 (0.57) | CA5ACA5BCA2BLMHPGD | |
| Sulfuric Acid SCHEMBL8529594 | 0.76 | — | — | |
| Isopropylhydroxylamine SCHEMBL245852 | 0.76 | — | — | |
| Sulfuric Acid SCHEMBL16470839 | 0.76 | TDP1 (0.53) | CA5ACA5BCA2BLMHPGD | |
| Sulfuric Acid SCHEMBL16344486 | 0.76 | TDP1 (0.53) | CA5ACA5BCA2BLMHPGD | |
| Sulfuric Acid SCHEMBL439606 | 0.76 | CA5A (0.40) | CA5ACA5BCA2BLMHPGD | |
| Sulfuric Acid SCHEMBL16344131 | 0.76 | CA5A (0.40) | CA5ACA5BCA2BLMHPGD | |
| Sulfuric Acid SCHEMBL9550776 | 0.76 | TDP1 (0.53) | CA5ACA5BCA2BLMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111518324-B | Environment-friendly oil-extended styrene-butadiene rubber and preparation method thereof | 中国石油天然气股份有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-111909313-B | In-situ reinforced styrene-butadiene latex as well as preparation method and application thereof | 山东京博中聚新材料有限公司 | 2022-07-15 | — | — | CN | claimed |
| CN-110357988-B | Composition for terminating free radical polymerization reaction and preparation method of styrene butadiene rubber | 中国石油天然气股份有限公司 | 2022-05-10 | — | — | CN | claimed |
| CN-111909313-A | In-situ enhanced styrene-butadiene latex as well as preparation method and application thereof | 山东京博中聚新材料有限公司 | 2020-11-10 | — | — | CN | claimed |
| CN-111518324-A | Environment-friendly oil-extended styrene-butadiene rubber and preparation method thereof | 中国石油天然气股份有限公司 | 2020-08-11 | — | — | CN | claimed |
| EP-0677535-A1 | Shortstopping of free radical polymerizations | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1995-10-18 | — | — | EP | claimed |
| US-5384372-A | TERMINATING EMULSION POLYMERIZATION BY ADDING ISOPROPYLHYDROXYLAMINE OR SALT THEREOF | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1995-01-24 | — | — | US | claimed |
| CN-111518324-B | Environment-friendly oil-extended styrene-butadiene rubber and preparation method thereof | 中国石油天然气股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-111909313-B | In-situ reinforced styrene-butadiene latex as well as preparation method and application thereof | 山东京博中聚新材料有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-110357988-B | Composition for terminating free radical polymerization reaction and preparation method of styrene butadiene rubber | 中国石油天然气股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-110357988-B | Composition for terminating free radical polymerization reaction and preparation method of styrene butadiene rubber | 中国石油天然气股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-111909313-A | In-situ enhanced styrene-butadiene latex as well as preparation method and application thereof | 山东京博中聚新材料有限公司 | 2020-11-10 | — | — | CN | disclosed |
| CN-111518324-A | Environment-friendly oil-extended styrene-butadiene rubber and preparation method thereof | 中国石油天然气股份有限公司 | 2020-08-11 | — | — | CN | disclosed |
| EP-2841470-A1 | ALKYL HYROXYLAMINE COMPOUNDS AND THEIR USE FOR SHORTSTOPPING FREE RADICAL POLYMERIZATIONS | Dow Global Technologies LLC (US) | 2015-03-04 | — | — | EP | disclosed |
| CN-103467656-B | Environment-friendly type terminating agent for styrene butadiene rubber emulsion polymerization and preparation method thereof | JILIN SHENGZHIYUAN CHEMICAL ADDITIVES CO., LTD. (CN) | 2014-10-01 | — | — | CN | disclosed |
| CN-103467656-A | Environment-friendly type terminating agent for styrene butadiene rubber emulsion polymerization and preparation method thereof | JILIN SHENGZHIYUAN CHEMICAL ADDITIVES CO LTD | 2013-12-25 | — | — | CN | disclosed |
| WO-2013188632-A1 | ALKYL HYROXYLAMINE COMPOUNDS AND THEIR USE FOR SHORTSTOPPING FREE RADICAL POLYMERIZATIONS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-12-19 | — | — | WO | disclosed |
| CN-1641071-A | Alkyl hydroxylamine and its salt electrochemical synthesis method | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-07-20 | — | — | CN | disclosed |
| EP-0677535-A1 | Shortstopping of free radical polymerizations | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |
| US-5384372-A | TERMINATING EMULSION POLYMERIZATION BY ADDING ISOPROPYLHYDROXYLAMINE OR SALT THEREOF | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1995-01-24 | — | — | US | disclosed |