Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.31 |
| ▸ | DHFR | P00374 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9188546 | 0.89 | TYR (0.37) | GABRA1GABRB2CYP3A4AR | |
| SCHEMBL9190686 | 0.89 | ALOX5 (0.33) | ARDHFR | |
| SCHEMBL9192796 | 0.85 | GABRA1 (0.38) | GABRA1GABRB2 | |
| SCHEMBL9195084 | 0.83 | GABRA1 (0.38) | GABRA1GABRB2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9194772 | 0.82 | AR (0.38) | ESR1ESR2AR | |
| SCHEMBL9190822 | 0.81 | GABRA1 (0.39) | GABRA1GABRB2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9187827 | 0.78 | CA1 (0.39) | GABRA1GABRB2TRPV1CYP1A2CYP3A4 | |
| SCHEMBL9190675 | 0.78 | HPN (0.46) | SMN1; SMN2LMNA | |
| SCHEMBL199968 | 0.78 | LMNA (0.40) | GABRA1GABRB2ARGPR84SMN1; SMN2 | |
| SCHEMBL8575917 | 0.78 | GABRA1 (0.39) | GABRA1GABRB2CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464844-B1 | Novel bis (4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1995-12-27 | — | — | EP | disclosed |
| US-5304668-A | Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents | MERRELL DOW PHARMACEUTICALS (US) | 1994-04-19 | — | — | US | disclosed |
| US-5281738-A | Anticholesterol agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0464844-A1 | Novel bis (4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |