Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9184089 | 0.86 | PLAU (0.55) | PPARGHDAC8HDAC6HDAC11EPHX2 | |
| SCHEMBL9184907 | 0.79 | PPARG (0.43) | PPARGHDAC8HDAC6HDAC11EPHX2 | |
| SCHEMBL9185683 | 0.79 | KCNQ3 (0.46) | PPARGHDAC8HDAC6HDAC11EPHX2 | |
| SCHEMBL9188860 | 0.79 | ITGB3 (0.47) | PPARGHDAC8HDAC6HDAC11EPHX2 | |
| SCHEMBL9184540 | 0.79 | PPARG (0.43) | PPARGHDAC8HDAC6HDAC11EPHX2 | |
| SCHEMBL9182305 | 0.79 | PAX8 (0.51) | PPARGHDAC8HDAC6HDAC11LMNA | |
| SCHEMBL9303677 | 0.79 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL9185692 | 0.79 | PPARG (0.42) | PPARGHDAC8HDAC6HDAC11EPHX2 | |
| SCHEMBL9185687 | 0.79 | PPARG (0.42) | PPARGHDAC8HDAC6HDAC11EPHX2 | |
| SCHEMBL9190826 | 0.78 | PPARG (0.43) | PPARGHDAC8HDAC6HDAC11EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476935-B1 | New indol and indoline derivatives | LILLY INDUSTRIES LTD (GB) | 1995-07-26 | — | — | EP | disclosed |
| US-5185361-A | Indole sulfonamides; Leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1993-02-09 | — | — | US | disclosed |
| EP-0476935-A1 | New indol and indoline derivatives | LILLY INDUSTRIES LIMITED (GB) | 1992-03-25 | — | — | EP | disclosed |