Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642132 | 0.82 | GAA (0.62) | SMN1; SMN2GAAMEN1KMT2ALMNA | |
| SCHEMBL8304862 | 0.82 | GAA (0.76) | SMN1; SMN2GAAMEN1KMT2ALMNA | |
| SCHEMBL9176062 | 0.81 | LMNA (0.57) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL6639356 | 0.80 | KMT2A (0.61) | SMN1; SMN2GAAMEN1KMT2ALMNA | |
| SCHEMBL3637063 | 0.79 | LMNA (0.68) | MEN1KMT2ALMNAALDH1A1HTT | |
| SCHEMBL9301197 | 0.79 | ALDH1A1 (0.57) | SMN1; SMN2GAAMEN1KMT2ALMNA | |
| SCHEMBL28684587 | 0.79 | LMNA (0.54) | SMN1; SMN2GAAMEN1KMT2ALMNA | |
| SCHEMBL9301023 | 0.79 | LMNA (0.54) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9190894 | 0.79 | PPARG (0.47) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9301541 | 0.78 | KMT2A (0.58) | SMN1; SMN2GAAMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |