Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 12/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670749 | 0.79 | LMNA (0.41) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9196171 | 0.75 | CA12 (0.41) | OGAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9662976 | 0.75 | ALDH1A1 (0.38) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL16060205 | 0.73 | SLC6A3 (0.53) | ALDH1A1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL1918767 | 0.72 | SLC6A2 (0.38) | ALDH1A1LMNAKDM4EHPGDPOLB | |
| Azetidine SCHEMBL5560125 | 0.70 | SLC6A2 (0.39) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL12337100 | 0.70 | KDM4E (0.51) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9192602 | 0.68 | SMN1; SMN2 (0.47) | OGAALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL17844445 | 0.68 | CYP2D6 (0.38) | MAPTMEN1KMT2ALMNAPOLB | |
| SCHEMBL9034432 | 0.66 | HTT (0.44) | ALDH1A1LMNATGFBR1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371564-B1 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-07-12 | — | — | EP | disclosed |
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |
| EP-0371564-A2 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |