Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | OGA | O60502 | 5/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196171 | 0.89 | CA12 (0.41) | SMN1; SMN2KDM5AALDH1A1MAPTLMNA | |
| SCHEMBL3418697 | 0.85 | TGFBR1 (0.42) | SMN1; SMN2KDM5ACHEK2 | |
| SCHEMBL7097024 | 0.81 | ALDH1A1 (0.51) | SMN1; SMN2KDM5AALDH1A1LMNAOGA | |
| SCHEMBL8917474 | 0.81 | MET (0.54) | SMN1; SMN2ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL17035971 | 0.77 | MET (0.43) | SMN1; SMN2KDM5AALDH1A1LMNAKDM4E | |
| SCHEMBL29660594 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MAPTLMNACHEK2 | |
| SCHEMBL3275241 | 0.75 | OGA (0.55) | ALDH1A1MAPTKDM4EOGAHPGD | |
| SCHEMBL30133836 | 0.75 | OGA (0.55) | ALDH1A1MAPTKDM4EOGAHPGD | |
| SCHEMBL8671295 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAKDM4ECA12CA1 | |
| SCHEMBL13373326 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTKDM4ECHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371564-B1 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-07-12 | — | — | EP | disclosed |
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |
| EP-0371564-A2 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |