Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fedotozine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.61 |
| ▸ | OPRD1 known ✓ | P41143 | 2/20 | 0.61 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.61 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.61 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.61 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fedotozine SCHEMBL9403100 | 1.00 | OPRM1 (0.61) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Fedotozine SCHEMBL6418832 | 0.90 | OPRM1 (0.63) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Fedotozine SCHEMBL154629 | 0.90 | OPRM1 (0.63) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Fedotozine SCHEMBL1649900 | 0.90 | OPRM1 (0.63) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Fedotozine SCHEMBL11137984 | 0.89 | ALDH1A1 (0.71) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Fedotozine SCHEMBL11137933 | 0.89 | ALDH1A1 (0.71) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| SCHEMBL11389394 | 0.79 | OPRM1 (0.51) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL14273976 | 0.76 | OPRM1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL25705 | 0.76 | OPRM1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| SCHEMBL9832151 | 0.76 | OPRM1 (0.46) | OPRM1OPRD1PDE4DNR1I2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389686-A | Analgesic properties of fedotozine | JOUVEINAL SA (FR) | 1995-02-14 | — | — | US | claimed |
| US-5389686-A | Analgesic properties of fedotozine | JOUVEINAL SA (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5362756-A | Gastrointestinal disorders | JOUVEINAL S.A. (FR) | 1994-11-08 | — | — | US | disclosed |