Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Fedotozine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.62 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.62 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.62 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.39 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fedotozine SCHEMBL11137984 | 1.00 | ALDH1A1 (0.71) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Fedotozine SCHEMBL1649900 | 0.91 | OPRM1 (0.63) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Fedotozine SCHEMBL154629 | 0.91 | OPRM1 (0.63) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Fedotozine SCHEMBL6418832 | 0.91 | OPRM1 (0.63) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Fedotozine SCHEMBL9191830 | 0.89 | OPRM1 (0.61) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Fedotozine SCHEMBL9403100 | 0.89 | OPRM1 (0.61) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Trimebutine SCHEMBL67225 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Trimebutine SCHEMBL5011979 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Trimebutine SCHEMBL1652810 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MAPK1LMNAOPRM1OPRD1 | |
| Trimebutine SCHEMBL28274910 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MAPK1LMNAOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4389331-A | Process for preparing pharmaceutically active compound-containing microcapsules | TANABE SEIYAKU CO., LTD. (JP) | 1983-06-21 | — | — | US | disclosed |