Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8676486 | 0.85 | SYK (0.45) | CYP11B2CYP11B1SLC22A12XDHCD274 | |
| SCHEMBL8678083 | 0.83 | LTB4R2 (0.43) | CYP11B2CYP11B1SLC22A12CD274 | |
| SCHEMBL8678897 | 0.83 | SYK (0.43) | CYP11B2CYP11B1SLC22A12ACMSDCD274 | |
| SCHEMBL8678448 | 0.83 | RARB (0.47) | CYP11B2CYP11B1SLC22A12CD274 | |
| SCHEMBL9192050 | 0.83 | CYP11B2 (0.37) | CYP11B2CYP11B1SLC22A12 | |
| SCHEMBL9192514 | 0.81 | SLC22A12 (0.40) | CYP11B2CYP11B1SLC22A12 | |
| SCHEMBL9186976 | 0.77 | MCL1 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL9193119 | 0.76 | XDH (0.43) | CYP11B2CYP11B1SLC22A12XDH | |
| SCHEMBL28844938 | 0.72 | ALDH1A1 (0.43) | — | |
| SCHEMBL4650767 | 0.71 | RARB (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464648-B1 | 4-Cyano-3-fluorophenyl esters | HOFFMANN LA ROCHE (CH) | 1995-12-06 | — | — | EP | disclosed |
| EP-0464648-A1 | 4-Cyano-3-fluorophenyl esters | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-08 | — | — | EP | disclosed |