Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 10/20 | 0.40 |
| ▸ | CA1 | P00915 | 10/20 | 0.40 |
| ▸ | CA4 | P22748 | 10/20 | 0.40 |
| ▸ | CA6 | P23280 | 10/20 | 0.40 |
| ▸ | CA7 | P43166 | 10/20 | 0.40 |
| ▸ | CA9 | Q16790 | 10/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 10/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 10/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 10/20 | 0.40 |
| ▸ | CA3 | P07451 | 8/20 | 0.40 |
| ▸ | CA5A | P35218 | 8/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9436726 | 0.80 | HPGD (0.62) | CA2HPGDCA12CA1CA4 | |
| Hydrochloric Acid SCHEMBL8899656 | 0.80 | SLC9A1 (0.47) | CNR2KMT2ASMN1; SMN2 | |
| SCHEMBL9192103 | 0.80 | SLC9A1 (0.57) | — | |
| SCHEMBL9191872 | 0.80 | CNR2 (0.39) | CA2CA12CA1CA4CA6 | |
| Hydrochloric Acid SCHEMBL8816045 | 0.79 | CNR2 (0.39) | CA2CA12CA1CA4CA6 | |
| Hydrochloric Acid SCHEMBL8896320 | 0.78 | SLC9A1 (0.47) | CNR2KMT2AMAPTLMNAHTT | |
| SCHEMBL9192656 | 0.77 | ALOX15 (0.46) | CA2HPGDCA1CA6CA7 | |
| SCHEMBL9190380 | 0.76 | KMT2A (0.39) | HPGDCNR2KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8896835 | 0.75 | SLC9A1 (0.49) | CNR2KMT2A | |
| Hydrochloric Acid SCHEMBL8915213 | 0.75 | PDE4A (0.37) | CA2CNR2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416499-B1 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AG (DE) | 1995-04-26 | — | — | EP | disclosed |
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |
| EP-0416499-A2 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-13 | — | — | EP | disclosed |