Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.45 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27248301 | 0.80 | TP53 (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9189988 | 0.78 | HCAR2 (0.56) | RAB9AHCAR2 | |
| SCHEMBL9195100 | 0.75 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2HCAR2TP53 | |
| SCHEMBL3817859 | 0.71 | TNKS2 (0.44) | SMN1; SMN2ALDH1A1HCAR2TP53 | |
| SCHEMBL1624031 | 0.71 | TNKS (0.50) | SMN1; SMN2HCAR2 | |
| SCHEMBL9501020 | 0.71 | HCAR2 (0.33) | ALDH1A1HCAR2KMT2A | |
| SCHEMBL1624717 | 0.70 | HCAR2 (0.55) | HCAR2PLA2G7DAO | |
| SCHEMBL9191917 | 0.69 | ADORA2A (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL9194911 | 0.69 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1HCAR2 | |
| SCHEMBL9190029 | 0.68 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399856-B1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA (FR) | 1995-08-09 | — | — | EP | disclosed |
| US-5270465-A | 4(3H)-pteridinone compounds | LIPHA, LYONNAISE INDUSTRILLE PHARMACEUTIQUE (FR) | 1993-12-14 | — | — | US | disclosed |
| US-5167949-A | Antiallergic | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1992-12-01 | — | — | US | disclosed |
| EP-0399856-A1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-11-28 | — | — | EP | disclosed |