Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9192595 | 0.91 | ACACB (0.42) | PTGESACACBASIC3ALOX5 | |
| SCHEMBL9476083 | 0.88 | ALOX5 (0.52) | PTGESAKR1C3ASIC3ALOX5EPHX2 | |
| SCHEMBL9189969 | 0.88 | ALOX5 (0.43) | PTGESACACBALOX5 | |
| SCHEMBL9191848 | 0.85 | PTGES (0.50) | PTGESACACBALOX5 | |
| SCHEMBL9190507 | 0.84 | PTGES (0.51) | PTGESAKR1C3ACACBALOX5EPHX2 | |
| SCHEMBL9197190 | 0.83 | PTGES (0.45) | PTGESAKR1C3ACACBASIC3ALOX5 | |
| SCHEMBL9195594 | 0.82 | ACACB (0.46) | PTGESACACBALOX5 | |
| SCHEMBL9193333 | 0.81 | PTGES (0.49) | PTGESALOX5 | |
| SCHEMBL9197314 | 0.80 | ALOX5 (0.36) | PTGESALOX5 | |
| SCHEMBL4537646 | 0.79 | PTGES (0.50) | PTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468281-B1 | Substituted phenylacetylenes, pharmaceuticals containing them and methods for the preparation of these compounds and pharmaceuticals | GRUENENTHAL GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5202349-A | Lipoxygenase inhibitors, antiasthatics | GRUENENTHAL GMBH (DE) | 1993-04-13 | — | — | US | disclosed |
| EP-0468281-A1 | Substituted phenylacetylenes, pharmaceuticals containing them and methods for the preparation of these compounds and pharmaceuticals | Grünenthal GmbH (DE) | 1992-01-29 | — | — | EP | disclosed |